Calculation of fraction of dose absorbed: comparison between analytical solution based on one compartment steady state concentration approximation and dynamic seven compartment model
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چکیده
منابع مشابه
Calculation of fraction of dose absorbed: comparison between analytical solution based on one compartment steady state concentration approximation and dynamic seven compartment model
Oral absorption of a drug is modeled by the differential equations for dissolution, permeation and gastrointestinal transit processes. The purpose of the present study was to compare simple approximate analytical solutions with full numerical solutions for the calculation of the fraction of a dose absorbed (Fa). The GI compartment model for numerical integration consisted of 1 stomach, 7 intest...
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ژورنال
عنوان ژورنال: Chem-Bio Informatics Journal
سال: 2009
ISSN: 1347-0442,1347-6297
DOI: 10.1273/cbij.9.75